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A distinction should be drawn between general travellers' diarrhoea, and severe diarrhoea.The former which is more of an annoyance than a major problem, can normally be clocked up to changes in diet, time-zone, irregular eating and general stress.
Nonetheless if you are new to travel, independent travel or travel in more challenging parts of the world (undeveloped) knowing it in advance should make your trip less daunting.
To quote from a book about climbing Mount Everest, the author stated that the hardest challenge with mountaineering in Nepal is not getting sick in Kathmandu!
But that doesn't mean that every trip to Nepal, India or the like will see you with the runs or throwing up; a normal healthy experience is quite possible with a bit of common sense and a fair size chunk of luck. So are all the cold salads, ice cubes in drinks, fruit juices, hand-made ice creams, raw food and buffet warnings.
The dirty culprits are normally cooks not washing their hands after a trip to the toilet, but even if the restaurant cook does not understand basic hygiene you will be safe if your food has been properly cooked and arrives piping hot.
Whatever causes it or wherever it came from doesn't really matter - try to let diarrhoea pass through you with plenty of water, a basic diet and maybe try apple sliced very thin then left to turn brown.
It goes without saying that the longer you are away the higher your chances of picking something up becomes although equally you will build up resistance over time. Bacteria and injected water can be inside melons, so many say it's best to avoid melons. Paranoia, for example about ice on hot days in popular tourist hot-spots really is unnecessary.
Many have eaten all of the above which are risky, and been fine.
And remember keep your own hands clean before you eat.
Some of the easiest places to get ill are where there are large numbers of tourists and the locals have adapted by offering western type food and/or a lot of food is saved, stored and re-heated. You might never have a problem in India, eating Indian food, but suffer in Nepal eating western style food.
Best advice: don't get paranoid about food poisoning otherwise it can cloud a trip and your experiences of some great food.
Just allow time for it, and take the rough with the smooth, as it were - there is very little you can do about it once the poison is inside you apart from avoiding dehydration (Gatorade type sports drinks are much easier to drink than water and will replace a little energy/salt), get plenty of rest and let it come out of you (in whatever form - severe and continual vomiting that is preventing you from keeping water down and/or retching for long periods can be treated by tablets or an injection; either way consult a doctor if symptoms are persisting.
You will probably be at a loss as to what has caused it and you just have to wait it out.